Ro60-0175
Sign in to saveRo60-0175, or Ro-600175, also known as '(S)-5-fluoro-6-chloro-α-methylisotryptamine ((S)-5-F-6-Cl-isoAMT'), is a serotonin 5-HT2 receptor agonist of the isotryptamine family developed by Hoffmann–La Roche, which has applications in scientific research. It is the enantiopure (S)- isomer of the 5-fluoro and 6-chloro derivative of α-methylisotryptamine (isoAMT).
Wikidata facts
- Mass
- 342.078263
Show 3 more facts
- chemical formula
- C₁₅H₁₆ClFN₂O₄
- isomeric SMILES
- C[C@@H](CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=C/C(=O)O)\C(=O)O
- canonical SMILES
- CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O
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Ro60-0175, or Ro-600175, also known as '(S)-5-fluoro-6-chloro-α-methylisotryptamine ((S)-5-F-6-Cl-isoAMT'), is a serotonin 5-HT2 receptor agonist of the isotryptamine family developed by Hoffmann–La Roche, which has applications in scientific research. It is the enantiopure (S)- isomer of the 5-fluoro and 6-chloro derivative of α-methylisotryptamine (isoAMT).
It acts as a potent and selective agonist of both the serotonin 5-HT2B and 5-HT2C receptor subtypes, with good selectivity over the closely related serotonin 5-HT2A subtype, and little or no affinity at other receptors. However, Ro60-0175 also activates the serotonin 5-HT2A receptor less potently than the serotonin 5-HT2B and 5-HT2C receptors. Its and values have been found to be 0.91–2.4nM (79–130%) at the serotonin 5-HT2B receptor, 32–52nM (84–88%) at the serotonin 5-HT2C receptor, and 400–447nM (69–91%) at the serotonin 5-HT2A receptor.