ABCC1

Also known as ABC29, ABCC, GS-X, MRP, MRP1, ATP binding cassette subfamily C member 1, DFNA77

Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene.

Gene data

ABCC1

Name: ATP binding cassette subfamily C member 1 (ABCC1 blood group)
Type: protein-coding
Aliases: ABC29, ABCC, DFNA77, GS-X, MRP, MRP1

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012].

via MyGene.info

Wikidata facts

Image: Protein ABCC1 PDB 2cbz.png

Show 5 more facts

exact match: identifiers.org/ncbigene/4363
HomoloGene ID: 133779
genomic start: 15949138
genomic end: 16143257
cytogenetic location: 16p13.11

Sources (5)

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Article

13 sections

Contents

Function
Structure
Genomic location and tissue expression
Clinical significance
Effect of polymorphisms
Alzheimer's disease
Role in cancer
Animal studies
Interactive pathway map
See also
References
Further reading
External links

Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene.

== Function == The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.