ABCC2

Also known as ABC30, CMOAT, DJS, MRP2, cMRP, Multidrug resistance-associated protein 2, ATP binding cassette subfamily C member 2

protein-coding gene in the species Homo sapiens

Gene data

ABCC2

Name: ATP binding cassette subfamily C member 2
Type: protein-coding
Position: 99,782,640–99,853,670 (+)
Aliases: ABC30, CMOAT, DJS, MRP2, cMRP
Ensembl: ENSG00000023839
RefSeq RNA: NM_000392.5, XM_006717630.4, XM_006717631.5, XM_011539291.4, XM_017015675.3
RefSeq protein: NP_000383.2, XP_006717693.1, XP_006717694.1, XP_011537593.1, XP_016871164.1

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008].