ABCG2

Also known as ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338,

Gene data

ABCG2

Name: ATP binding cassette subfamily G member 2 (JR blood group)
Type: protein-coding
Position: 88,090,150–88,231,818 (−)
Aliases: ABC15, ABCP, BCRP, BMDP, CD338, CDw338, CDw388, EST157481, GOUT1, MRX
Ensembl: ENSG00000118777
RefSeq RNA: NM_001257386.2, NM_001348985.1, NM_001348986.2, NM_001348987.1, NM_001348988.1
RefSeq protein: NP_001244315.1, NP_001335914.1, NP_001335915.1, NP_001335916.1, NP_001335917.1

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].

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Article

7 sections

Contents

Function
Interactive pathway map
Inhibition
See also
References
Further reading
External links

thumb|ABCG2 with simulated plasma membrane

ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation protein used to actively pump drugs and other compounds against their concentration gradient using the bonding and hydrolysis of ATP as the energy source.