ABCG2
Sign in to saveAlso known as ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338
thumb|ABCG2 with simulated plasma membrane
Gene data
ABCG2- Name
- ATP binding cassette subfamily G member 2 (JR blood group)
- Type
- protein-coding
- Position
- 88,088,127–88,231,818 (−)
- Aliases
- ABC15, ABCP, BCRP, BMDP, CD338, CDw338, CDw388, EST157481, GOUT1, MRX
- Ensembl
- ENSG00000118777
- RefSeq RNA
- NM_001257386.2, NM_001348985.1, NM_001348986.2, NM_001348987.1, NM_001348988.1
- RefSeq protein
- NP_001244315.1, NP_001335914.1, NP_001335915.1, NP_001335916.1, NP_001335917.1
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ATP binding cassette subfamily G member 2 (JR blood group)
- Symbol
- ABCG2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:88,088,127-88,231,818
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~4 min read
Encyclopedic overview
7 sectionsContents
- Function
- Interactive pathway map
- Inhibition
- See also
- References
- Further reading
- External links
thumb|ABCG2 with simulated plasma membrane
ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation protein used to actively pump drugs and other compounds against their concentration gradient using the bonding and hydrolysis of ATP as the energy source.
Excerpted from Wikipedia’s “ABCG2” article, available under the CC BY-SA 4.0 licence.