ACE2
Sign in to saveAlso known as ACEH, angiotensin I converting enzyme 2, ACE 2
Gen der Spezies Homo sapiens
Key facts
- Pdb
- Ortholog search: PDBe RCSB
via Wikipedia infobox
Gene data
ACE2- Name
- angiotensin converting enzyme 2
- Type
- protein-coding
- Chromosome
- X
- Position
- 15,494,290–15,607,236 (−)
- Aliases
- ACEH
- Ensembl
- ENSG00000130234
- RefSeq RNA
- NM_001371415.1, NM_001386259.1, NM_001386260.1, NM_001388452.1, NM_001389402.1
- RefSeq protein
- NP_001358344.1, NP_001373188.1, NP_001373189.1, NP_001375381.1, NP_001376331.1
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
angiotensin converting enzyme 2
- Symbol
- ACE2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:15,494,290-15,607,236
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ACE2 PDB 1r42.png
Show 9 more facts
- HomoloGene ID
- 41448
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/59272
- genomic end
- 15620271
- chromosome
- human X chromosome
- genomic start
- 15579156
- cytogenetic location
- Xp22.2
- on focus list of Wikimedia project
- WikiProject COVID-19
- Commons category
- Angiotensin converting enzyme 2, ACE2
via Wikidata · CC0
Article · Deutsch
Angiotensin-konvertierendes Enzym 2 (englisch Angiotensin-converting enzyme 2, kurz ACE2) ist eine Metallocarboxypeptidase und ein Typ-1-Transmembranprotein mit Homologie zum Angiotensin-konvertierenden Enzym (ACE), das hauptsächlich in Eukaryoten, aber auch in Bakterien vorkommt. ACE2 spielt eine wichtige Rolle im Renin-Angiotensin-Aldosteron-System (RAAS), das den Volumenhaushalt des menschlichen Körpers steuert und den Blutdruck reguliert. PCR-Analysen ergeben, dass ACE2 im Herzen sowie in der Lunge, Niere, im Endothel und im Magen-Darm-Trakt exprimiert ist. Außerdem ist ACE2 ein Rezeptor für verschiedene Coronaviren, einschließlich SARS-CoV und SARS-CoV-2, um in Zellen zu gelangen. Dieses Bindungsverhalten stellt einen vielversprechenden Mechanismus für eine mögliche Behandlung dar.
Abstract from DBpedia / Wikipedia · CC BY-SA