ACE2
Sign in to saveAlso known as ACEH, angiotensin I converting enzyme 2, ACE 2
gene da espécie Homo sapiens
In the Vinony graph
Within Vinony's link graph, ACE2 is referenced by 91 other articles, and connects out to Coronavirus, PubMed and PubMed Central.
Vinony files it under EC 3.4.17, Genes on human chromosome X and Single-pass transmembrane proteins.
Its subject is documented across 30 Wikipedia language editions.
Key facts
- Pdb
- Ortholog search: PDBe RCSB
via Wikipedia infobox
Gene data
ACE2- Name
- angiotensin converting enzyme 2
- Type
- protein-coding
- Chromosome
- X
- Position
- 15,494,290–15,607,236 (−)
- Aliases
- ACEH
- Ensembl
- ENSG00000130234
- RefSeq RNA
- NM_001371415.1, NM_001386259.1, NM_001386260.1, NM_001388452.1, NM_001389402.1
- RefSeq protein
- NP_001358344.1, NP_001373188.1, NP_001373189.1, NP_001375381.1, NP_001376331.1
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
angiotensin converting enzyme 2
- Symbol
- ACE2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:15,494,290-15,607,236
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ACE2 PDB 1r42.png
Show 9 more facts
- HomoloGene ID
- 41448
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/59272
- genomic end
- 15620271
- chromosome
- human X chromosome
- genomic start
- 15579156
- cytogenetic location
- Xp22.2
- on focus list of Wikimedia project
- WikiProject COVID-19
- Commons category
- Angiotensin converting enzyme 2, ACE2
via Wikidata · CC0
Article · Português
A enzima conversora da angiotensina 2 ECA 2 é tudo uma enzima componente do sistema renina angiotensina aldosterona. É responsável pela conversão da angiotensina II em angiotensina 1-7(Ang 1-7). Sua importância médica reside no fato de estar relacionada a patogênese de várias desordens cardiovasculares, como por exemplo, hipertensão, arteriosclerose e infarto do miocárdio. A enzima conversora da angiotensina(ECA) é produzida pelos vasos pulmonares e age sobre a angiotensina-1, transformando-a em angiotensina-2. O gene ACE2 atua como um receptor do vírus SARS-CoV2. Mutações no gene ACE2 podem influenciar a capacidade do vírus de reconhecer e infectar uma célula humana.
Abstract from DBpedia / Wikipedia · CC BY-SA