ACE2
Sign in to saveAlso known as ACEH, angiotensin I converting enzyme 2, ACE 2
gen van de soort Homo sapiens
In the Vinony graph
Within Vinony's link graph, ACE2 is referenced by 91 other articles, and connects out to Coronavirus, PubMed and PubMed Central.
Vinony files it under EC 3.4.17, Genes on human chromosome X and Single-pass transmembrane proteins.
Its subject is documented across 30 Wikipedia language editions.
Key facts
- Pdb
- Ortholog search: PDBe RCSB
via Wikipedia infobox
Gene data
ACE2- Name
- angiotensin converting enzyme 2
- Type
- protein-coding
- Chromosome
- X
- Position
- 15,494,290–15,607,236 (−)
- Aliases
- ACEH
- Ensembl
- ENSG00000130234
- RefSeq RNA
- NM_001371415.1, NM_001386259.1, NM_001386260.1, NM_001388452.1, NM_001389402.1
- RefSeq protein
- NP_001358344.1, NP_001373188.1, NP_001373189.1, NP_001375381.1, NP_001376331.1
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
angiotensin converting enzyme 2
- Symbol
- ACE2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:15,494,290-15,607,236
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ACE2 PDB 1r42.png
Show 9 more facts
- HomoloGene ID
- 41448
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/59272
- genomic end
- 15620271
- chromosome
- human X chromosome
- genomic start
- 15579156
- cytogenetic location
- Xp22.2
- on focus list of Wikimedia project
- WikiProject COVID-19
- Commons category
- Angiotensin converting enzyme 2, ACE2
via Wikidata · CC0
Article · Nederlands
Angiotensine-converterend enzym 2, ook wel afgekort tot ACE 2 is een exopeptidase dat de omzetting van angiotensine I naar het nonapeptide angiotensine 1-9, of de omzetting van angiotensine II naar angiotensine 1-7 katalyseert. ACE 2 heeft directe invloed op functioneren van het hart en vaatstelsel. Het enzym bevindt zich dan ook voornamelijk in vasculaire endotheelcellen van het hart en de nieren. De ACE 2-receptoren zijn in studies aangewezen als plek waar het SARSr-coronavirus mensen binnentreedt. Het coronavirus SARS-CoV-2 blijkt een 10 tot 20 keer hogere affiniteit om een verbinding aan te gaan met ACE 2 in vergelijking tot het SARS-CoV.
Abstract from DBpedia / Wikipedia · CC BY-SA