An acetyltransferase (also referred to as a transacetylase) is any of a class of transferase enzymes that transfers an acetyl group in a reaction called acetylation. In biological organisms, post-translational modification of a protein via acetylation can profoundly transform its functionality by altering various properties like hydrophobicity, solubility, and surface attributes. These alterations have the potential to influence the protein's conformation and its interactions with substrates, cofactors, and other macromolecules.
An acetyltransferase (also referred to as a transacetylase) is any of a class of transferase enzymes that transfers an acetyl group in a reaction called acetylation. In biological organisms, post-translational modification of a protein via acetylation can profoundly transform its functionality by altering various properties like hydrophobicity, solubility, and surface attributes. These alterations have the potential to influence the protein's conformation and its interactions with substrates, cofactors, and other macromolecules.
== Types of acetyltransferases == {| class="wikitable" |+Table 1: Types of acetyltransferases found in humans |Acetyltransferases |Substrate |Gene |Chromosome locus in humans |Gene group |Abbreviation |- |Histone acetyltransferase |Lysine residues of histones |HAT1 |2q31.1 |Lysine acetyltransferases |HAT |- |Choline acetyltransferase |Choline |CHAT |10q11.23 |NA |ChAT |- |Serotonin N-acetyltransferase |Serotonin |AANAT |17q25.1 |GCN5-related N-acetyltransferases |AANAT |- |NatA acetyltransferase |N-terminus of various proteins as they emerge from the ribosome |NAA15 |4q31.1 |Armadillo-like helical domain containing N-alpha-acetyltransferase subunits |NatA |- |NatB acetyltransferase |Peptides starting with Met-Asp/Glu/Asn/Gln |NAA25 |12q24.13 |N-alpha-acetyltransferase subunits of microRNA protein-coding host genes |NatB |}
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).