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acute lymphocytic leukemia

File:Morphological_types_of_acute_lymphoblastic_leukemia.jpg · Wikimedia Commons · See Wikimedia Commons

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acute lymphocytic leukemia

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Also known as ALL, acute lymphoblastic leukemia, acute lymphoblastic leukaemia, acute lymphoid leukemia, acute lymphocytic leukaemia, acute lymphoid leukaemia

leukemia that is characterized by over production of lymphoblasts.

Key facts

Other names
Acute lymphocytic leukemia, acute lymphoid leukemia
Specialty
Hematology , oncology
Symptoms
Feeling tired, pale color, fever, easy bleeding or bruising, bone pain, enlarged lymph nodes
Complications
Infection , tumor lysis syndrome
Usual onset
2–5 years old
Types
B-cell ALL , T-cell ALL
Causes
Usually unknown
Risk factors
Identical twin with ALL, Down syndrome , Fanconi anemia , ataxia telangiectasia , Klinefelter syndrome , high birth weight , significant radiation exposure
Diagnostic method
Blood tests and bone marrow examination
Differential diagnosis
Infectious mononucleosis , acute myeloid leukemia , lymphoblastic lymphoma , aplastic anemia
Treatment
Chemotherapy , stem cell transplantation , radiation therapy , targeted therapy
Prognosis
Children : 90% five-year survival rate , Adults : 35% five-year survival
Frequency
1 in 1,750 children
Deaths
111,000 (2015)

via Wikipedia infobox

Described at

What Is Acute Lymphocytic Leukemia | American Cancer Society

Acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, is a cancer that starts from white blood cells called lymphocytes in the bone marrow.

cancer.org →

Acute lymphocytic leukemia (ALL) is a cancer that starts in your bone marrow (the soft inner part of certain bones, where new blood cells are made). With this type of leukemia, the cancer cells usually invade your blood fairly quickly. They can also sometimes spread to other parts of your body, including your lymph nodes, liver, spleen, central nervous system (brain and spinal cord), testicles (in males), and other organs. Cancer starts when cells in the body begin to grow out of control. Cells in nearly any part of the body can become cancer cells. Learn more here. Leukemias are cancers that start in cells that would normally develop into different types of blood cells. Most often, leukemia starts in early forms of white blood cells, but some leukemias start in other blood cell types. There are several types of leukemia. They are divided based mainly on whether the leukemia is acute (fast growing) or chronic (slower growing), and whether it starts in myeloid cells or lymphoid cells. ALL isn’t the only cancer that starts in the lymphocytes. Other types of cancer, such as lymphomas , also start in these cells. (This is true of non-Hodgkin lymphoma and Hodgkin lymphoma .) Leukemias mainly affect the bone marrow and blood. Lymphomas mainly affect the lymph nodes or other organs, although they may also involve the bone marrow. Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO). National Cancer Institute. Acute Lymphoblastic Leukemia Treatment (PDQ®)–Patient Version. 2025. Accessed at on May 5, 2025. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia. Version 3.2024. Accessed at on May 5, 2025.

Excerpt from a page describing this subject · 16,719 chars · not written by Vinony

Wikidata facts

Subclass of
disease
Image
Acute leukemia-ALL.jpg
Show 14 more facts
NCI Thesaurus ID
C3167
health specialty
oncology
Commons category
Acute lymphoblastic leukemia
genetic association
IKZF1
symptoms and signs
dyspnea
ICD-9-CM
204.0
drug or therapy used for treatment
teniposide
on focus list of Wikimedia project
WikiProject Medicine
short name
ALL
different from
ALL
Sources (11)

via Wikidata · CC0

~33 min read

Encyclopedic overview

Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated.

In most cases, the cause is unknown. Genetic risk factors may include Down syndrome, Li–Fraumeni syndrome, or neurofibromatosis type 1. Environmental risk factors may include significant radiation exposure or prior chemotherapy. Evidence regarding electromagnetic fields or pesticides is unclear. Some hypothesize that an abnormal immune response to a common infection may be a trigger. The underlying mechanism involves multiple genetic mutations that results in rapid cell division. The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, and platelets. Diagnosis is typically based on blood tests and bone marrow examination.

Excerpted from Wikipedia’s “acute lymphocytic leukemia” article, available under the CC BY-SA 4.0 licence.

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