IKZF1

Name

IKAROS family zinc finger 1

Type

protein-coding

Aliases

CVID13, Hs.54452, IK1, IKAROS, LYF1, LyF-1, PPP1R92, PRO0758, ZNFN1A1

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014].

via MyGene.info

Gene · Ensembl

IKAROS family zinc finger 1

Symbol

IKZF1

Biotype

Protein coding

Organism

Homo sapiens

Location

7:50,303,412-50,405,101

Strand

Forward (+)

Assembly

GRCh38

• Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.Science (New York, N.Y.) · 2014
• Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity.Immunity · 2024
• IKZF1(plus) Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
• IKZF1: An important target for the treatment of autoimmune diseases.Clinical immunology (Orlando, Fla.) · 2025
• IKZF1 in acute lymphoblastic leukemia: the rise before the fall?Leukemia & lymphoma · 2024

via PubMed

Wikidata facts

via Wikidata · CC0