teniposide

Also known as VM-26, Vumon®, 4'-demethylepipodophyllotoxin 9-(4,6-O-(R)-2-thenylidene-beta-D-glucopyranoside), Teniposidum, Epidophyllotoxin, Téniposide, Teniposido

Teniposide (trade name Vumon) is a chemotherapeutic medication used in the treatment of childhood acute lymphocytic leukemia (ALL), Hodgkin's lymphoma, certain brain tumours, and other types of cancer. It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body.

Research

1,514 papers

Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC.Journal for immunotherapy of cancer · 2022
Teniposide in lymphomas and leukemias.Seminars in oncology · 1992
Teniposide (VM-26) in brain tumors.Seminars in oncology · 1992
Teniposide: overview of its therapeutic potential in adult cancers.Cancer chemotherapy and pharmacology · 1994
Teniposide alone and in combination chemotherapy in small cell lung cancer.Seminars in oncology · 1992

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Wikidata facts

Mass: 656.156

Show 4 more facts

chemical formula: C₃₂H₃₂O₁₃S
canonical SMILES: COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)OC6C(C(C7C(O6)COC(O7)C8=CC=CS8)O)O
isomeric SMILES: COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O[C@H]6[C@@H]([C@H]([C@H]7[C@H](O6)CO[C@H](O7)C8=CC=CS8)O)O
Commons category: Teniposide

Sources (6)

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Article

9 sections

Contents

Medical uses
Administration
Contraindications
Side effects
Interactions
Pharmacology
Mechanism of action
Chemistry
References

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