acute myeloid leukemia
Also known as AML - acute Myeloid Leukemia, Leukemia, Myelocytic, acute, acute myeloblastic leukemia, acute myelogenous leukemia, Acute myelogenous leukemia; AML, Acute Granulocytic Leukemia, LEUKEMIA, ACUTE MYELOID; AML, Acute non lymphoblastic leukemia
myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells
Key facts
- Other names
- Acute myelogenous leukemia, acute nonlymphocytic leukemia (ANLL), acute myeloblastic leukemia, acute granulocytic leukemia
- Specialty
- Hematology , oncology
- Symptoms
- Feeling tired, shortness of breath , easy bruising and bleeding, increased risk of infection
- Usual onset
- 65–70 years old
- Risk factors
- Smoking , previous chemotherapy or radiation therapy , myelodysplastic syndrome , benzene
- Diagnostic method
- Bone marrow aspiration , blood test
- Treatment
- Chemotherapy , radiation therapy , stem cell transplant , Targeted inhibitors
- Prognosis
- Five-year survival ~33% (US, 2015–2021)
- Frequency
- 145,000 per year (2021)
- Deaths
- 130,000 (2021)
via Wikipedia infobox
Wikidata facts
Article
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. Symptoms may include feeling tired, shortness of breath, easy bruising, bleeding, and increased risk of infection. Occasionally, spread may occur to the brain, skin, or gums. As an acute leukemia, AML progresses rapidly, and is typically fatal within weeks or months if left untreated.
Risk factors include getting older, being male, smoking, previous chemotherapy or radiation therapy, myelodysplastic syndrome, and exposure to the chemical benzene. The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. Diagnosis is generally based on bone marrow aspiration and specific blood tests. AML has several subtypes for which treatments and outcomes may vary.