acyl-CoA
Sign in to savethumb|right|General chemical structure of an acyl-CoA, where R is a carboxylic acid side chain Acyl-CoA is a group of CoA-based coenzymes that metabolize carboxylic acids. Fatty acyl-CoA's are susceptible to beta oxidation, forming, ultimately, acetyl-CoA. The acetyl-CoA enters the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP, the common biochemical energy carrier.
Research
25,615 papers- Compartmentalised acyl-CoA metabolism and roles in chromatin regulation.Molecular metabolism · 2020
- Acyl-CoA metabolism and partitioning.Annual review of nutrition · 2014
- Roles of acyl-CoA-binding proteins in plant reproduction.Journal of experimental botany · 2022
- Peroxisomal acyl-CoA synthetases.Biochimica et biophysica acta · 2012
- Plant Cytosolic Acyl-CoA-Binding Proteins.Lipids · 2016
via PubMed
Article
8 sectionsContents
- Functions
- Fatty acid activation
- Beta oxidation of acyl-CoA
- Example using stearic acid
- Clinical significance
- See also
- References
- External links
thumb|right|General chemical structure of an acyl-CoA, where R is a carboxylic acid side chain Acyl-CoA is a group of CoA-based coenzymes that metabolize carboxylic acids. Fatty acyl-CoA's are susceptible to beta oxidation, forming, ultimately, acetyl-CoA. The acetyl-CoA enters the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP, the common biochemical energy carrier.
==Functions== ===Fatty acid activation=== Fats are broken down by conversion to acyl-CoA. This conversion is one response to high energy demands such as exercise. The oxidative degradation of fatty acids is a two-step process, catalyzed by acyl-CoA synthetase. Fatty acids are converted to their acyl phosphate, the precursor to acyl-CoA. The latter conversion is mediated by acyl-CoA synthase" acyl-P + HS-CoA → acyl-S-CoA + Pi + H+