follistatin
Sign in to saveAlso known as follistatin isoform FST317, activin-binding protein, FST
Follistatin, also known as activin-bindings protein, is a protein that in humans is encoded by the FST gene. Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.
Protein · UniProt
Follistatin
- Gene
- FST
- Organism
- Homo sapiens (Human)
- Length
- 344 aa
- Molecular mass
- 38,007 Da
- Evidence
- 1: Evidence at protein level
Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs) (PubMed:11279126, PubMed:16482217, PubMed:18535106). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (PubMed:16482217). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independ…
Swiss-Prot (reviewed) · via UniProt
Research
3,197 papers- Follistatin and follistatin-like 3 in metabolic disorders.Prostaglandins & other lipid mediators · 2023
- Activin/follistatin and atherosclerosis--a review.Journal of atherosclerosis and thrombosis · 1998
- Follistatin: a multifunctional regulatory protein.Frontiers in neuroendocrinology · 1998
- Circulating follistatin in relation to energy metabolism.Molecular and cellular endocrinology · 2016
- [Research progress of follistatin-related proteins in digestive system tumors].Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] · 2024
via PubMed
Clinical Trials
14 registered- NACOMPLETEDEffect of L-arginine on Microcirculation, Myogenesis and Angiogenesis Associated With Aging, Sarcopenia and DiabetesRio de Janeiro State University · NCT04112875
- NANOT_YET_RECRUITINGEffect of Acute Endurance Exercise on the Production of FGF21 and Follistatin in Patients With Hepatocellular CarcinomaUniversity Hospital, Clermont-Ferrand · NCT07189624
- PHASE1/PHASE2COMPLETEDClinical Intramuscular Gene Transfer of rAAV1.CMV.huFollistatin344 Trial to Patients With Duchenne Muscular DystrophyJerry R. Mendell · NCT02354781
- COMPLETEDFollistatin Levels in Metabolically Healthy and Unhealthy Obese IndividualsGoztepe Prof Dr Suleyman Yalcın City Hospital · NCT06229899
- PHASE1/PHASE2RECRUITINGCALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene TherapyUnlimited Biotechnology LLC · NCT07443826
- COMPLETEDAssociation of the Mediterranean Diet With Fertility OutcomesHarokopio University · NCT03050944
~5 min read
Encyclopedic overview
6 sectionsContents
- Biochemistry
- Function
- Clinical significance
- References
- Further reading
- External links
Follistatin, also known as activin-bindings protein, is a protein that in humans is encoded by the FST gene. Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.
Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone.
Excerpted from Wikipedia’s “follistatin” article, available under the CC BY-SA 4.0 licence.