adrenoceptor beta 3

Protein · UniProt

Beta-3 adrenergic receptor

Gene

ADRB3

Organism

Homo sapiens (Human)

Length

408 aa

Molecular mass

43,519 Da

Evidence

1: Evidence at protein level

G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively (PubMed:10188996, PubMed:2570461, PubMed:8641219). The rank order of potency for physiological agonists is norepinephrine > epinephrine (PubMed:10188996, PubMed:2570461, PubMed:8641219). Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis (By similarity). Also activates lipolytic process by…

• Beta-adrenoceptor polymorphisms.Naunyn-Schmiedeberg's archives of pharmacology · 2004
• Regulation of beta 3-adrenoceptor expression in white fat cells.Fundamental & clinical pharmacology · 1995
• Function and regulation of the beta 3-adrenoceptor.Trends in pharmacological sciences · 1996
• β(3) -adrenoceptor agonists inhibit calcium oscillations in bladder detrusor.BJU international · 2018
• Structures of Adrenoceptors.Handbook of experimental pharmacology · 2024

via PubMed

• COMPLETED
  Composur: Study to Understand the Performance of Vibegron in Participants with Overactive Bladder (OAB)Urovant Sciences GmbH · NCT05067478
• PHASE3COMPLETED
  A Study to Examine the Safety and Efficacy of a New Drug in Patients With Symptoms of Overactive Bladder (OAB)Urovant Sciences GmbH · NCT03492281
• PHASE2COMPLETED
  Study to Evaluate the Efficacy and Safety of Vibegron Administered Orally for 12 Weeks to Women With Irritable Bowel SyndromeUrovant Sciences GmbH · NCT03806127
• PHASE3COMPLETED
  Extension Study of Vibegron in Men With Overactive Bladder (OAB) Symptoms on Pharmacological Therapy for Benign Prostatic HyperplasiaUrovant Sciences GmbH · NCT04103450
• PHASE2COMPLETED
  Assessment of Efficacy of Mirabegron, a New beta3-adrenergic Receptor in the Prevention of Heart FailureJean-Luc Balligand · NCT02599480
• NACOMPLETED
  Study of the Effect of Beta-3 Adrenergic Receptor Agonists on Oxidative Stress and Signalling Pathways Implicated in Remodelling of the Uteroplacental Space: Experimental in Vitro Approach on Myometrial Tissue ExplantsCentre Hospitalier Universitaire Dijon · NCT02862886

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

via Wikidata · CC0