Dopamine receptor D3

Protein · UniProt

D(3) dopamine receptor

Gene

DRD3

Organism

Homo sapiens (Human)

Length

400 aa

Molecular mass

44,195 Da

Evidence

1: Evidence at protein level

Dopamine receptor that is primarily expressed in limbic areas of the brain and is involved in the modulation of cognitive, emotional, and endocrine functions (PubMed:39984436). Plays a key role in regulating neuronal signaling pathways associated with motivation, reward, and behavior (PubMed:39984436). Coupled to G(i)/G(o) proteins; activation leads to inhibition of adenylate cyclase and decreased intracellular cAMP levels (PubMed:10578130). Involved in the control of locomotor activity and implicated in several neuropsychiatric disorders, including schizophrenia and substance use disorders…

• Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?Ageing research reviews · 2020
• D3 dopamine receptor, behavioral sensitization, and psychosis.Neuroscience and biobehavioral reviews · 2001
• The D3 dopamine receptor and substance dependence.Journal of addictive diseases · 2001
• Dopamine D3 receptor: basic and clinical aspects.Clinical neuropharmacology · 1993
• Dopamine D3 receptor agonists as pharmacological tools.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015

via PubMed

• PHASE1COMPLETED
  Study of Oral ABBV-932 Capsules to Evaluate Dopamine D2 and D3 Receptor Occupancy in Brain in Adult Healthy VolunteersAbbVie · NCT06300580
• PHASE1ACTIVE_NOT_RECRUITING
  Study of Radiotracer [18F]Fluortriopride ([18F]FTP) by PET/CTUniversity of Pennsylvania · NCT02379338
• COMPLETED
  Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine DependenceCentre for Addiction and Mental Health · NCT01984177
• PHASE1/PHASE2ACTIVE_NOT_RECRUITING
  Evaluation of D3 Receptor Occupancy Using FLUORTRIOPRIDE ([18F]FTP) PET/CTUniversity of Pennsylvania · NCT02815917
• PHASE1/PHASE2COMPLETED
  Exploring Occupancy of Dopamine D3 Receptor by Buspirone in Humans Using PETCentre for Addiction and Mental Health · NCT01699828
• NACOMPLETED
  Exploring Regulation and Function of Dopamine D3 Receptors in Alcohol Use Disorders: A [11C]-(+)-PHNO StudyCentre for Addiction and Mental Health · NCT03037060

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

Image

3PBL (D3).png

via Wikidata · CC0