Dopamine receptor D3
Sign in to saveAlso known as Dopamine D3 receptor, D(3) dopamine receptor, Receptors, Dopamine D3, essential tremor 1, DRD3
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, Dopamine receptor D3 is referenced by 748 other articles, and connects out to PubMed, Ensembl genome database project and protein.
Vinony files it under Biology of attention deficit hyperactivity disorder, Dopamine receptors and Genes on human chromosome 3.
Its subject is documented across 12 Wikipedia language editions.
Protein · UniProt
D(3) dopamine receptor
- Gene
- DRD3
- Organism
- Homo sapiens (Human)
- Length
- 400 aa
- Molecular mass
- 44,195 Da
- Evidence
- 1: Evidence at protein level
Dopamine receptor that is primarily expressed in limbic areas of the brain and is involved in the modulation of cognitive, emotional, and endocrine functions (PubMed:39984436). Plays a key role in regulating neuronal signaling pathways associated with motivation, reward, and behavior (PubMed:39984436). Coupled to G(i)/G(o) proteins; activation leads to inhibition of adenylate cyclase and decreased intracellular cAMP levels (PubMed:10578130). Involved in the control of locomotor activity and implicated in several neuropsychiatric disorders, including schizophrenia and substance use disorders…
Swiss-Prot (reviewed) · via UniProt
Research
5,045 papers- Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?Ageing research reviews · 2020
- D3 dopamine receptor, behavioral sensitization, and psychosis.Neuroscience and biobehavioral reviews · 2001
- The D3 dopamine receptor and substance dependence.Journal of addictive diseases · 2001
- Dopamine D3 receptor: basic and clinical aspects.Clinical neuropharmacology · 1993
- Dopamine D3 receptor agonists as pharmacological tools.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015
via PubMed
Clinical Trials
17 registered- PHASE1COMPLETEDStudy of Oral ABBV-932 Capsules to Evaluate Dopamine D2 and D3 Receptor Occupancy in Brain in Adult Healthy VolunteersAbbVie · NCT06300580
- PHASE1ACTIVE_NOT_RECRUITINGStudy of Radiotracer [18F]Fluortriopride ([18F]FTP) by PET/CTUniversity of Pennsylvania · NCT02379338
- COMPLETEDEffects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine DependenceCentre for Addiction and Mental Health · NCT01984177
- PHASE1/PHASE2ACTIVE_NOT_RECRUITINGEvaluation of D3 Receptor Occupancy Using FLUORTRIOPRIDE ([18F]FTP) PET/CTUniversity of Pennsylvania · NCT02815917
- PHASE1/PHASE2COMPLETEDExploring Occupancy of Dopamine D3 Receptor by Buspirone in Humans Using PETCentre for Addiction and Mental Health · NCT01699828
- NACOMPLETEDExploring Regulation and Function of Dopamine D3 Receptors in Alcohol Use Disorders: A [11C]-(+)-PHNO StudyCentre for Addiction and Mental Health · NCT03037060
Wikidata facts
- Instance of
- protein
- Image
- 3PBL (D3).png
Show 3 more facts
- found in taxon
- Homo sapiens
- exact match
- www.ncbi.nlm.nih.gov/protein/P35462
- Commons category
- DRD3
Sources (7)
via Wikidata · CC0