ALAD

Name

aminolevulinate dehydratase

Type

protein-coding

Position

113,386,304–113,401,356 (−)

Aliases

ALADH, PBGS

Ensembl

ENSG00000148218

RefSeq RNA

NM_000031.6, NM_001003945.3, NM_001317745.2, XM_011518364.3, XM_047422944.1

RefSeq protein

NP_000022.3, NP_001003945.1, NP_001304674.1, XP_011516666.1, XP_047278900.1

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

via MyGene.info

Gene · Ensembl

aminolevulinate dehydratase

Symbol

ALAD

Biotype

Protein coding

Organism

Homo sapiens

Location

9:113,386,304-113,401,356

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

ALADwithZinc 1ylv ALADwithLead 1qnv.png

via Wikidata · CC0