ENO1
Sign in to saveAlso known as ENO1L1, MPB1, NNE, PPH, HEL-S-17, enolase 1
Enolase 1 (ENO1), more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase, in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1.
Gene data
ENO1- Name
- enolase 1
- Type
- protein-coding
- Position
- 8,854,043–8,879,308 (−)
- Aliases
- ENO1-IT1, ENO1L1, HEL-S-17, MPB1, NNE, PPH
- Ensembl
- ENSG00000074800
- RefSeq RNA
- NM_001201483.4, NM_001353346.3, NM_001428.5
- RefSeq protein
- NP_001188412.1, NP_001340275.1, NP_001419.1
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
enolase 1
- Symbol
- ENO1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:8,854,043-8,879,308
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ENO1 PDB 2PSN.png
Show 8 more facts
- HomoloGene ID
- 134343
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2023
- genomic end
- 8879190
- genomic start
- 8861000
- chromosome
- human chromosome 1
- cytogenetic location
- 1p36.23
- expressed in
- ascending aorta
Sources (4)
via Wikidata · CC0
~6 min read
Encyclopedic overview
13 sectionsContents
- Structure
- Relationship to Myc-binding protein-1
- Function
- Clinical significance
- Cancer
- Autoimmune disease
- Gastrointestinal disease
- Hemolytic anemia
- Interactive pathway map
- Interactions
- See also
- External links
- References
Enolase 1 (ENO1), more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase, in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.
== Structure == ENO1 is one of three enolase isoforms, the other two being ENO2 (ENO-γ) and ENO3 (ENO-β). Each isoform is a protein subunit that can hetero- or homodimerize to form αα, αβ, αγ, ββ, and γγ dimers. The ENO1 gene spans 18 kb and lacks a TATA box while possessing multiple transcription start sites. A hypoxia-responsive element can be found in the ENO1 promoter and allows the enzyme to function in aerobic glycolysis and contribute to the Warburg effect in tumor cells.
Excerpted from Wikipedia’s “ENO1” article, available under the CC BY-SA 4.0 licence.