Ferrochelatase
Sign in to saveAlso known as heme synthase, ferrochelatase, mitochondrial, heme synthetase, FECH, protoheme ferro-lyase, protoporphyria
Protoporphyrin ferrochelatase (EC 4.98.1.1, formerly EC 4.99.1.1, or ferrochelatase; systematic name protoheme ferro-lyase (protoporphyrin-forming)) is an enzyme encoded by the FECH gene in humans. Ferrochelatase catalyses the eighth and terminal step in the biosynthesis of heme, converting protoporphyrin IX into heme B. It catalyses the reaction:
In the Vinony graph
Within Vinony's link graph, Ferrochelatase is referenced by 41 other articles, and connects out to PubMed, PubMed Central and lyase.
Vinony files it under EC 4.99.1, Genes on human chromosome 18 and Peripheral membrane proteins.
Its subject is documented across 15 Wikipedia language editions.
Key facts
- Enzyme.align
- right
- Enzyme.name
- Protoporphyrin ferrochelatase
- Enzyme.image
- 1hrk.jpg
- Enzyme.image_size
- 270
- Enzyme.caption
- Ferrochelatase homodimer, Human
- Enzyme.EC_number
- 4.98.1.1
- Enzyme.CAS_number
- 9012-93-5
- Enzyme.GO_code
- 0004325
via Wikipedia infobox
Protein · UniProt
Ferrochelatase, mitochondrial
- Gene
- FECH
- Organism
- Homo sapiens (Human)
- Length
- 423 aa
- Molecular mass
- 47,862 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the ferrous insertion into protoporphyrin IX and participates in the terminal step in the heme biosynthetic pathway
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
30 registered- RECRUITINGLongitudinal Study of the PorphyriasThe American Porphyrias Expert Collaborative · NCT01561157
- NACOMPLETEDOral Iron for Erythropoietic ProtoporphyriasIcahn School of Medicine at Mount Sinai · NCT02979249
- PHASE3COMPLETEDMulticentre Phase III Erythropoietic Protoporphyria StudyClinuvel Pharmaceuticals Limited · NCT04053270
- PHASE2ENROLLING_BY_INVITATIONGATEWAY: A Phase 2a Study of PORT-77 in Adults With Erythropoietic ProtoporphyriaPortal Therapeutics, Inc. · NCT06971900
- COMPLETEDErythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial ImpactIcahn School of Medicine at Mount Sinai · NCT01688895
- TEMPORARILY_NOT_AVAILABLEExpanded Access Program of Bitopertin For Participants With EPP or XLPDisc Medicine, Inc · NCT07603401
Wikidata facts
- Instance of
- protein
Show 3 more facts
- exact match
- purl.uniprot.org/uniprot/P22830
- cell component
- mitochondrion
- found in taxon
- Homo sapiens
via Wikidata · CC0
~6 min read
Encyclopedic overview
9 sectionsContents
- Function
- Structure
- Mechanism
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
Protoporphyrin ferrochelatase (EC 4.98.1.1, formerly EC 4.99.1.1, or ferrochelatase; systematic name protoheme ferro-lyase (protoporphyrin-forming)) is an enzyme encoded by the FECH gene in humans. Ferrochelatase catalyses the eighth and terminal step in the biosynthesis of heme, converting protoporphyrin IX into heme B. It catalyses the reaction:
== Function ==
Excerpted from Wikipedia’s “Ferrochelatase” article, available under the CC BY-SA 4.0 licence.