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alfadolone
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Alfadolone (INN), or alphadolone is a neuroactive steroid and general anesthetic. Along with alfaxolone, as alfadolone acetate, it is one of the components of the anesthetic drug mixture althesin.
Chemical data
- Formula
- C21H32O4
- Molecular weight
- 348.5 g/mol
- IUPAC name
- (3R,5S,8S,9S,10S,13S,14S,17S)-3-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one
- SMILES
- C[C@]12CC[C@H](C[C@@H]1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O
- InChIKey
- XWYBFXIUISNTQG-VKMGZQQJSA-N
- XLogP
- 2.6
- Polar surface area
- 74.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
855 papers- Methohexitone.British journal of anaesthesia · 1976
- Anaesthesia.The Practitioner · 1976
- Althesin.Anaesthesia · 1985
- Anaesthetic steroids--a review.Indian journal of medical sciences · 1993
- General intravenous anesthetics - pharmacodynamics, pharmacokinetics and chiral properties.Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti · 2023
via PubMed
Wikidata facts
- Mass
- 348.23005950399994
Show 4 more facts
- chemical formula
- C₂₁H₃₂O₄
- canonical SMILES
- CC12CCC(CC1CCC3C2C(=O)CC4(C3CCC4C(=O)CO)C)O
- subject has role
- anesthetic
- isomeric SMILES
- C[C@]12CC[C@H](C[C@@H]1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Chemistry
- See also
- References
Alfadolone (INN), or alphadolone is a neuroactive steroid and general anesthetic. Along with alfaxolone, as alfadolone acetate, it is one of the components of the anesthetic drug mixture althesin.
==Chemistry==
Excerpted from Wikipedia’s “alfadolone” article, available under the CC BY-SA 4.0 licence.