alfaxalone
Sign in to saveAlso known as 5α-alphaxalone, alfadione, alphaxolone
Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan and Faxone, is a neuroactive steroid and general anesthetic which is used currently in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic. The most common side effect seen in current veterinary practice is respiratory depression when Alfaxan is administered concurrently with other sedative and anesthetic drugs; when premedications are not given, veterinary patients also become agitated and hypersensitive when waking up.
Research
1,649 papers- Alfaxalone-Xylazine Anesthesia in Laboratory Mice (Mus musculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2019
- Alfaxalone for anesthesia of a giant snake.Veterinary anaesthesia and analgesia · 2022
- A review of the pharmacology and clinical application of alfaxalone in cats.Veterinary journal (London, England : 1997) · 2015
- Clinical review of the pharmacological and anaesthetic effects of alfaxalone in dogs.The Journal of small animal practice · 2022
- Alfaxalone for total intravenous anaesthesia in horses.Veterinary anaesthesia and analgesia · 2019
via PubMed
Wikidata facts
- Mass
- 332.235145
Show 5 more facts
- Commons category
- Alphaxolone
- chemical formula
- C₂₁H₃₂O₃
- isomeric SMILES
- CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)C
- canonical SMILES
- CC(=O)C1CCC2C1(CC(=O)C3C2CCC4C3(CCC(C4)O)C)C
- subject has role
- anesthetic
Sources (2)
via Wikidata · CC0
~11 min read
Encyclopedic overview
15 sectionsContents
- Veterinary use
- Available forms
- Specific populations
- Side effects
- Overdose
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Availability
- References
Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan and Faxone, is a neuroactive steroid and general anesthetic which is used currently in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic. The most common side effect seen in current veterinary practice is respiratory depression when Alfaxan is administered concurrently with other sedative and anesthetic drugs; when premedications are not given, veterinary patients also become agitated and hypersensitive when waking up.
Alfaxalone works as a positive allosteric modulator on GABAA receptors and, at high concentrations, as a direct agonist of the GABAA receptor. It is cleared quickly by the liver, giving it a relatively short terminal half-life and preventing it from accumulating in the body, lowering the chance of overdose.
Excerpted from Wikipedia’s “alfaxalone” article, available under the CC BY-SA 4.0 licence.