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Difludiazepam
Sign in to saveDifludiazepam (Ro07-4065) is a benzodiazepine derivative which is the 2',6'-difluoro derivative of fludiazepam. It was invented in the 1970s but was never marketed, and has been used as a research tool to help determine the shape and function of the GABAA receptors, at which it has an IC50 of 4.1nM. Difludiazepam has subsequently been sold as a designer drug, and was first notified to the EMCDDA by Swedish authorities in 2017.
In the Vinony graph
Within Vinony's link graph, Difludiazepam is referenced by 179 other articles, and connects out to benzodiazepine drug, alphenal and zapizolam.
It sits within the topics Benzodiazepines, Chemical pages without DrugBank identifier and Drugs missing an ATC code.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C16H11ClF2N2O
- Molecular weight
- 320.72 g/mol
- IUPAC name
- 7-chloro-5-(2,6-difluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
- SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=C(C=CC=C3F)F
- InChIKey
- DUNFPASORLTEGN-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 32.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 320.05279709200005
Show 3 more facts
- Commons category
- Difludiazepam
- canonical SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=C(C=CC=C3F)F
- chemical formula
- C₁₆H₁₁ClF₂N₂O
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Difludiazepam (Ro07-4065) is a benzodiazepine derivative which is the 2',6'-difluoro derivative of fludiazepam. It was invented in the 1970s but was never marketed, and has been used as a research tool to help determine the shape and function of the GABAA receptors, at which it has an IC50 of 4.1nM. Difludiazepam has subsequently been sold as a designer drug, and was first notified to the EMCDDA by Swedish authorities in 2017.
== See also == Diclazepam Flubromazepam Ro07-3953 Ro07-5220 SH-I-048A
Excerpted from Wikipedia’s “Difludiazepam” article, available under the CC BY-SA 4.0 licence.