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Difludiazepam

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Difludiazepam (Ro07-4065) is a benzodiazepine derivative which is the 2',6'-difluoro derivative of fludiazepam. It was invented in the 1970s but was never marketed, and has been used as a research tool to help determine the shape and function of the GABAA receptors, at which it has an IC50 of 4.1nM. Difludiazepam has subsequently been sold as a designer drug, and was first notified to the EMCDDA by Swedish authorities in 2017.

Wikidata facts

Mass
320.05279709200005
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Commons category
Difludiazepam
canonical SMILES
CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=C(C=CC=C3F)F
chemical formula
C₁₆H₁₁ClF₂N₂O
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Encyclopedic overview

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Difludiazepam (Ro07-4065) is a benzodiazepine derivative which is the 2',6'-difluoro derivative of fludiazepam. It was invented in the 1970s but was never marketed, and has been used as a research tool to help determine the shape and function of the GABAA receptors, at which it has an IC50 of 4.1nM. Difludiazepam has subsequently been sold as a designer drug, and was first notified to the EMCDDA by Swedish authorities in 2017.

== See also == Diclazepam Flubromazepam Ro07-3953 Ro07-5220 SH-I-048A

Excerpted from Wikipedia’s “Difludiazepam” article, available under the CC BY-SA 4.0 licence.

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