Also known as anaplastic lesion
Anaplasia () is a condition of cells with poor cellular differentiation, losing the morphological characteristics of mature cells and their orientation with respect to each other and to endothelial cells. The term also refers to a group of morphological changes in a cell (nuclear pleomorphism, altered nuclear-cytoplasmic ratio, presence of nucleoli, high proliferation index) that point to a possible malignant transformation.
via PubMed
逆行性生長(Anaplasia),是指成熟的正常細胞非正常地復歸未成熟的細胞,為惡性腫瘤(malignant neoplasms)的指標性症狀。大多數癌細胞會導致細胞去分化,讓細胞無限制的分裂。但發生在幹細胞的癌症,不會導致逆行性生長,而是使幹細胞無法分化。 逆行性生長的細胞也往往形成巨核以及合胞體,正常細胞的N/C值(細胞核和細胞的比例)約為1:4或1:6,逆行性生長的細胞的N/C值約為1:1,N/C值的上升會造成細胞深染,為辨識細胞去分化與否的重要特性。除此之外,明顯非典型的大量有絲分裂現象也是重要的特徵,也可能在分裂時產生多個主軸,出現三極或四極的情形。此外,未分化的細胞通常不能識別其發展的方向(即失去正常的極性)。 逆行性生長是細胞突變最嚴重的狀態,且為不可逆性疾病。在此之前,細胞的可逆但非正常時期被稱為分生不良(dysplasia)
Abstract from DBpedia / Wikipedia · CC BY-SA
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).