angiopoietin
Also known as angiopoietins
Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from preexisting blood vessels. Angiogenesis proceeds through sprouting, endothelial cell migration, proliferation, and vessel destabilization and stabilization. They are responsible for assembling and disassembling the endothelial lining of blood vessels. Angiopoietin cytokines are involved in controlling microvascular permeability, vasodilation, and vasoconstri
Key facts
- Protein.Name
- angiopoietin 2
- Protein.HGNCid
- 485
- Protein.Symbol
- ANGPT2
- Protein.EntrezGene
- 285
- Protein.OMIM
- 601922
- Protein.RefSeq
- NM_001147
- Protein.UniProt
- O15123
- Protein.Chromosome
- 8
- Protein.Arm
- p
- Protein.Band
- 23
- Protein.LocusSupplementaryData
- .3-8q23
- Protein.caption
- Crystal structure of the human angiopoietin-2 receptor binding domain.
- Protein.image
Article
12 sectionsContents
- Structure
- Only clusters/multimers activate receptors
- Specific mechanisms
- Tie pathway
- Tie-2
- Angiogenesis signaling
- Vascular permeability signaling
- Angiopoietin-1 and the Tie2
- Cancer
- Clinical relevance
- References
- External links
Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from preexisting blood vessels. Angiogenesis proceeds through sprouting, endothelial cell migration, proliferation, and vessel destabilization and stabilization. They are responsible for assembling and disassembling the endothelial lining of blood vessels. Angiopoietin cytokines are involved in controlling microvascular permeability, vasodilation, and vasoconstriction by signaling smooth muscle cells surrounding vessels. There are now four identified angiopoietins: ANGPT1, ANGPT2, ANGPTL3, ANGPT4.
In addition, there are a number of proteins that are closely related to ('like') angiopoietins (Angiopoietin-related protein 1, , , , , , , ).