ANGPTL3
Sign in to saveAlso known as ANG-5, ANGPT5, ANL3, FHBL2, angiopoietin like 3
Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene.
Gene data
ANGPTL3- Name
- angiopoietin like 3
- Type
- protein-coding
- Position
- 62,597,464–62,607,699 (+)
- Aliases
- ANG-5, ANGPT5, ANL3, FHBL2
- Ensembl
- ENSG00000132855
- RefSeq RNA
- NM_014495.4
- RefSeq protein
- NP_055310.1
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
angiopoietin like 3
- Symbol
- ANGPTL3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:62,597,464-62,607,699
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- ANGPTL3.png
Show 8 more facts
- HomoloGene ID
- 8499
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/27329
- genomic end
- 62606313
- genomic start
- 62597520
- chromosome
- human chromosome 1
- cytogenetic location
- 1p31.3
- expressed in
- stomach
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- References
- Further reading
- External links
Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene.
== Function ==
Excerpted from Wikipedia’s “ANGPTL3” article, available under the CC BY-SA 4.0 licence.