AQP1

Also known as AQP-CHIP, CHIP28, CO, aquaporin 1 (Colton blood group)

Aquaporin 1 (AQP-1) is a protein that in humans is encoded by the AQP1 gene.

Gene data

AQP1

Name: aquaporin 1 (Colton blood group)
Type: protein-coding
Position: 30,911,720–30,925,517 (+)
Aliases: AQP-CHIP, CHIP28, CO
Ensembl: ENSG00000240583
RefSeq RNA: NM_000385.3, NM_001185060.1, NM_001185061.1, NM_001185062.1, NM_001329872.2
RefSeq protein: NP_001316801.1, NP_932766.1

This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016].

Gene Ontology

Biological process

renal water homeostasis renal water transport

~2 min read

Article

5 sections

Contents

Function
See also
References
Further reading
External links

Aquaporin 1 (AQP-1) is a protein that in humans is encoded by the AQP1 gene.

AQP-1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, lungs, and the central nervous system.