ITPR3
Sign in to saveAlso known as IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3
Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.
Gene data
ITPR3- Name
- inositol 1,4,5-trisphosphate receptor type 3
- Type
- protein-coding
- Position
- 33,620,331–33,696,575 (+)
- Aliases
- CMT1J, IMD132, IMD133, IP3R, IP3R-3, IP3R3
- Ensembl
- ENSG00000096433
- RefSeq RNA
- NM_002224.4, XM_011514577.4, XM_017010832.2, XM_047418731.1, XM_047418732.1
- RefSeq protein
- NP_002215.2, XP_011512879.1, XP_016866321.1, XP_047274687.1, XP_047274688.1
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
inositol 1,4,5-trisphosphate receptor type 3
- Symbol
- ITPR3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:33,620,331-33,696,575
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- See also
- References
- Further reading
- External links
Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.
== Function ==
Excerpted from Wikipedia’s “ITPR3” article, available under the CC BY-SA 4.0 licence.