CLIC4
Sign in to saveAlso known as CLIC4L, H1, MTCLIC, huH1, p64H1, chloride intracellular channel 4
Chloride intracellular channel 4, also known as CLIC4,p644H1,HuH1, is a eukaryotic gene.
Gene data
CLIC4- Name
- CLIC family member 4
- Type
- protein-coding
- Position
- 24,745,342–24,844,324 (+)
- Aliases
- CLIC4L, H1, MTCLIC, huH1, p64H1
- Ensembl
- ENSG00000169504
- RefSeq RNA
- NM_013943.3, XM_054335865.1, XM_054335866.1
- RefSeq protein
- NP_039234.1, XP_054191840.1, XP_054191841.1
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
chloride intracellular channel 4
- Symbol
- CLIC4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:24,745,342-24,844,324
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CLIC4 PDB 2ahe.png
Show 8 more facts
- exact match
- identifiers.org/ncbigene/25932
- HomoloGene ID
- 8490
- found in taxon
- Homo sapiens
- genomic end
- 24844321
- genomic start
- 24745382
- chromosome
- human chromosome 1
- cytogenetic location
- 1p36.11
- expressed in
- urethra
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Binding partners
- See also
- References
- Further reading
- External links
Chloride intracellular channel 4, also known as CLIC4,p644H1,HuH1, is a eukaryotic gene.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the clic4 gene, is a member of the p64 family; the gene is expressed in many tissues. These channels are implicated in angiogenesis, pulmonary hypertension, cancer, and cardioprotection from ischemia-reperfusion injury. They exhibit an intracellular vesicular pattern in PANC-1 cells (pancreatic cancer cells).
Excerpted from Wikipedia’s “CLIC4” article, available under the CC BY-SA 4.0 licence.