ATG16L1
Sign in to saveAlso known as autophagy related 16-like 1 (S. cerevisiae), APG16L, ATG16A, ATG16L, IBD10, WDR30, autophagy related 16 like 1
Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. This protein is characterized as a subunit of the autophagy-related ATG12-ATG5/ATG16 complex and is essentially important for the LC3 (ATG8) lipidation and autophagosome formation. This complex localizes to the membrane and is released just before or after autophagosome completion.
Gene data
ATG16L1- Name
- autophagy related 16 like 1
- Type
- protein-coding
- Position
- 233,210,051–233,295,674 (+)
- Aliases
- APG16L, ATG16A, ATG16L, IBD10, WDR30
- Ensembl
- ENSG00000281089
- RefSeq RNA
- NM_001190266.2, NM_001190267.2, NM_001363742.2, NM_017974.4, NM_030803.7
- RefSeq protein
- NP_001177195.1, NP_001177196.1, NP_001350671.1, NP_060444.3, NP_110430.5
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
autophagy related 16 like 1
- Symbol
- ATG16L1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HG2232_PATCH:155,389-241,012
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~5 min read
Encyclopedic overview
6 sectionsContents
- Function
- Structure
- Clinical significance
- References
- Further reading
- External links
Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. This protein is characterized as a subunit of the autophagy-related ATG12-ATG5/ATG16 complex and is essentially important for the LC3 (ATG8) lipidation and autophagosome formation. This complex localizes to the membrane and is released just before or after autophagosome completion.
Furthermore, ATG16L1 appears to have other autophagy-independent functions, e.g., intracellular membrane trafficking regulation and inflammation. Autophagy in general plays a crucial role in pathways leading to innate and adaptive immunity activation. That is why many autophagy-related proteins, including ATG16L1, their gene expression and its role in autoimmune diseases are studied in-depth nowadays.
Excerpted from Wikipedia’s “ATG16L1” article, available under the CC BY-SA 4.0 licence.