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autophagosome
Sign in to saveAlso known as autophagic vacuole, GO:0005776
thumb|The autophagic process is divided into five distinct stages: Initiation, phagophore nucleation, autophagosomal formation (elongation), autophagosome-lysosome fusion (autophagolysosome) and cargo degradation. An autophagosome is a spherical structure with double layer membranes. It is the key structure in macroautophagy, the intracellular degradation system for cytoplasmic contents (e.g., abnormal intracellular proteins, excess or damaged organelles, invading microorganisms). After formation, autophagosomes deliver cytoplasmic components to the lysosomes. The outer membrane of an autophag
In the Vinony graph
Within Vinony's link graph, autophagosome is referenced by 128 other articles, and connects out to autophagy, mammal and protein.
It is catalogued under topics including Cell anatomy, Cell biology and Eukaryotic cell anatomy.
Its subject is documented across 13 Wikipedia language editions.
Research
15,937 papers- Autophagosome-Lysosome Fusion.Journal of molecular biology · 2020
- Mechanisms governing autophagosome biogenesis.Nature reviews. Molecular cell biology · 2020
- Autophagosome Biogenesis.Cells · 2023
- Machinery, regulation and pathophysiological implications of autophagosome maturation.Nature reviews. Molecular cell biology · 2021
- Autophagosome Biogenesis Machinery.Journal of molecular biology · 2020
via PubMed
Wikidata facts
- Subclass of
- vacuole
Show 1 more fact
- exact match
- purl.obolibrary.org/obo/GO_0005776
Sources (3)
via Wikidata · CC0
~6 min read
Encyclopedic overview
5 sectionsContents
- Autophagosome formation
- Function in neurons
- Clinical relevance
- See also
- References
thumb|The autophagic process is divided into five distinct stages: Initiation, phagophore nucleation, autophagosomal formation (elongation), autophagosome-lysosome fusion (autophagolysosome) and cargo degradation. An autophagosome is a spherical structure with double layer membranes. It is the key structure in macroautophagy, the intracellular degradation system for cytoplasmic contents (e.g., abnormal intracellular proteins, excess or damaged organelles, invading microorganisms). After formation, autophagosomes deliver cytoplasmic components to the lysosomes. The outer membrane of an autophagosome fuses with a lysosome to form an autolysosome. The lysosome's hydrolases degrade the autophagosome-delivered contents and its inner membrane.
The formation of autophagosomes is regulated by genes that are well-conserved from yeast to higher eukaryotes. The nomenclature of these genes has differed from paper to paper, but it has been simplified in recent years. The gene families formerly known as APG, AUT, CVT, GSA, PAZ, and PDD are now unified as the ATG (AuTophaGy related) family.
Excerpted from Wikipedia’s “autophagosome” article, available under the CC BY-SA 4.0 licence.