Autoimmune regulator

Protein · UniProt

Autoimmune regulator

Gene

AIRE

Organism

Homo sapiens (Human)

Length

545 aa

Molecular mass

57,727 Da

Evidence

1: Evidence at protein level

Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylate…

• NACOMPLETED
  Comparison Between Hypoglycemic Counter Regulatory Responses in Type 1 Diabetics vs Control SubjectsUniversity of Aarhus · NCT03034226
• UNKNOWN
  The Role of Regulatory T Cell in Patients With Type 1 Diabetes MellitusNational Taiwan University Hospital · NCT00173641
• PHASE2RECRUITING
  Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)Paul Szabolcs · NCT07284641
• UNKNOWN
  Complement Regulatory Proteins Expression and Clinical Response in Rheumatoid Arthritis (RA) Patients Treated With RituximabHospital de Clinicas de Porto Alegre · NCT01096069
• PHASE1COMPLETED
  Autologous Ex Vivo Expanded Regulatory T Cells in Ulcerative ColitisUniversity of Erlangen-Nürnberg Medical School · NCT04691232
• NOT_YET_RECRUITING
  Eosinophil Subpopulations in Eosinophilic-associated DiseasesUniversity of Florence · NCT06911775

via ClinicalTrials.gov