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GeneQ17916609· pop 5· linked from 811 articles

ELK3

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Also known as ERP, NET, SAP2, SAP-2, ELK3, ETS transcription factor, ETS transcription factor ELK3

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

Gene data

ELK3
Name
ETS transcription factor ELK3
Type
protein-coding
Position
96,193,978–96,269,835 (+)
Aliases
ERP, NET, SAP-2, SAP2
Ensembl
ENSG00000111145
RefSeq RNA
NM_001303511.2, NM_001413760.1, NM_001413761.1, NM_001413762.1, NM_001413763.1
RefSeq protein
NP_001290440.1, NP_001400689.1, NP_001400690.1, NP_001400691.1, NP_001400692.1

This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].

Gene Ontology

Pathways

ID signaling pathway

via MyGene.info

Gene · Ensembl

ETS transcription factor ELK3

Symbol
ELK3
Biotype
Protein coding
Organism
Homo sapiens
Location
12:96,193,978-96,269,835
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

4 sections
Contents
  • Interactions
  • References
  • Further reading
  • External links

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.

Excerpted from Wikipedia’s “ELK3” article, available under the CC BY-SA 4.0 licence.

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