Structure via PubChem · Public domain (PubChem)
avapritinib
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Avapritinib, sold under the brand name Ayvakit among others, is a medication used for the treatment of advanced systemic mastocytosis and indolent systemic mastocytosis. It is also used for the treatment of tumors due to one specific rare mutation: it is specifically intended for adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) that harbor a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation. Avapritinib is a kinase inhibitor.
Chemical data
- Formula
- C26H27FN10
- Molecular weight
- 498.6 g/mol
- IUPAC name
- (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine
- SMILES
- C[C@](C1=CC=C(C=C1)F)(C2=CN=C(N=C2)N3CCN(CC3)C4=NC=NN5C4=CC(=C5)C6=CN(N=C6)C)N
- InChIKey
- DWYRIWUZIJHQKQ-SANMLTNESA-N
- XLogP
- 1.9
- Polar surface area
- 106 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 498.24041908400005
- Has use
- medication
Show 4 more facts
- chemical formula
- C₂₆H₂₇FN₁₀
- isomeric SMILES
- Cn1cc(cn1)c2cn3ncnc(N4CCN(CC4)c5ncc(cn5)[C@@](C)(N)c6ccc(F)cc6)c3c2
- canonical SMILES
- Cn1cc(-c2cc3c(N4CCN(c5ncc(C(C)(N)c6ccc(F)cc6)cn5)CC4)ncnn3c2)cn1
- subject has role
- protein kinase inhibitors
Sources (1)
via Wikidata · CC0
~6 min read
Encyclopedic overview
5 sectionsContents
- Medical uses
- History
- References
- Further reading
- External links
{{Infobox drug | image = Avapritinib.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = A va PRI ti nib | tradename = Ayvakit, Ayvakyt | Drugs.com = | MedlinePlus = a620013 | DailyMedID = Avapritinib | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = Antineoplastic agent | ATC_prefix = L01 | ATC_suffix = EX18 | ATC_supplemental =
Excerpted from Wikipedia’s “avapritinib” article, available under the CC BY-SA 4.0 licence.