AXIN2

Also known as AXIL, ODCRCS, axin 2

Axin-2, also known as axin-like protein (Axil), axis inhibition protein 2 (AXIN2), or conductin, is a protein that in humans is encoded by the AXIN2 gene.

Gene data

AXIN2

Name: axin 2
Type: protein-coding
Position: 65,528,561–65,562,067 (−)
Aliases: AXIL, ODCRCS
Ensembl: ENSG00000168646
RefSeq RNA: NM_001363813.1, NM_004655.4, XM_011525319.3, XM_011525320.2, XM_011525321.3
RefSeq protein: NP_001350742.1, NP_004646.3, XP_011523621.1, XP_011523622.1, XP_011523623.1

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008].

Pathways

Wnt signaling pathway - Homo sapiens (human)Hippo signaling pathway - Homo sapiens (human)Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)Cushing syndrome - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Colorectal cancer - Homo sapiens (human)Endometrial cancer - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

axin 2

Symbol: AXIN2
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:65,528,561-65,562,067
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 6 more facts

Commons category: Axin-2
HomoloGene ID: 3420
exact match: identifiers.org/ncbigene/8313
genomic end: 65561648
genomic start: 63524681
cytogenetic location: 17q24.1

Sources (7)

via Wikidata · CC0

~3 min read

Article

6 sections

Contents

Function
Clinical significance
Interactions
Further reading
References
External links

Axin-2, also known as axin-like protein (Axil), axis inhibition protein 2 (AXIN2), or conductin, is a protein that in humans is encoded by the AXIN2 gene.

== Function ==