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catenin
EntityQ384104· pop 16· linked from 356 articles

Also known as Catenins

thumb|350px|Interactions of structural proteins at a cadherin-based adherens junction. The exact means by which [[cadherins are linked to actin filaments is still under investigation.]]

~13 min read

Article

8 sections
Contents
  • Types
  • Function
  • Interaction with cadherins
  • Clinical significance
  • Recent clinical studies
  • Catenins and cancer
  • References
  • External links

thumb|350px|Interactions of structural proteins at a cadherin-based adherens junction. The exact means by which [[cadherins are linked to actin filaments is still under investigation.]]

Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-Catenin can bind to β-catenin and can also bind filamentous actin (F-actin). β-Catenin binds directly to the cytoplasmic tail of classical cadherins. Additional catenins such as γ-catenin and δ-catenin have been identified. The name "catenin" was originally selected ('catena' means 'chain' in Latin) because it was suspected that catenins might link cadherins to the cytoskeleton.

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