catenin
Sign in to saveAlso known as Catenins
thumb|350px|Interactions of structural proteins at a cadherin-based adherens junction. The exact means by which [[cadherins are linked to actin filaments is still under investigation.]]
Research
57,681 papers- p120-catenin in canonical Wnt signaling.Critical reviews in biochemistry and molecular biology · 2017
- Delta-catenin at the synaptic-adherens junction.Trends in cell biology · 2005
- Cadherin-catenin proteins in vertebrate development.Current opinion in cell biology · 2006
- The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis.Science advances · 2024
- p120-Catenin: a novel regulator of innate immunity and inflammation.Critical reviews in immunology · 2012
via PubMed
~13 min read
Article
8 sectionsContents
- Types
- Function
- Interaction with cadherins
- Clinical significance
- Recent clinical studies
- Catenins and cancer
- References
- External links
thumb|350px|Interactions of structural proteins at a cadherin-based adherens junction. The exact means by which [[cadherins are linked to actin filaments is still under investigation.]]
Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-Catenin can bind to β-catenin and can also bind filamentous actin (F-actin). β-Catenin binds directly to the cytoplasmic tail of classical cadherins. Additional catenins such as γ-catenin and δ-catenin have been identified. The name "catenin" was originally selected ('catena' means 'chain' in Latin) because it was suspected that catenins might link cadherins to the cytoskeleton.