AXL

Name

AXL receptor tyrosine kinase

Type

protein-coding

Position

41,219,174–41,261,766 (+)

Aliases

ARK, AXL3, JTK11, Tyro7, UFO

Ensembl

ENSG00000167601

RefSeq RNA

NM_001278599.2, NM_001699.6, NM_021913.5

RefSeq protein

NP_001265528.1, NP_001690.2, NP_068713.2

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021].

via MyGene.info

Wikidata facts

Image

Protein AXL PDB 2c5d.png

via Wikidata · CC0