HCK

Also known as JTK9, p59Hck, p61Hck, HCK proto-oncogene, Src family tyrosine kinase

Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.

Gene data

HCK

Name: HCK proto-oncogene, Src family tyrosine kinase
Type: protein-coding
Aliases: AIPCV, JTK9, p59Hck, p61Hck

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010].

via MyGene.info

Gene · Ensembl

HCK proto-oncogene, Src family tyrosine kinase

Symbol: HCK
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:32,052,197-32,101,857
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein HCK PDB 1ad5.png

Show 5 more facts

HomoloGene ID: 20489
exact match: identifiers.org/ncbigene/3055
genomic start: 32052197
genomic end: 30689659
cytogenetic location: 20q11.21

Sources (3)

via Wikidata · CC0

~3 min read

Article

6 sections

Contents

Structure
Signaling
Function
Interactions
References
Further reading

Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.

== Structure == HCK comprises five distinct domains which include two terminal domains and three SH domains. The N-terminal domain is important for lipid modifications and a C-terminal domain includes a regulatory tyrosine residue. Next, HCK comprises three highly conserved SH domains: SH1, SH2, and SH3. The catalytic SH1 domain houses the kinase's active site. The regulatory SH3 and SH2 domains are tightly bound together when HCK is in an inactive state.