Also known as JTK9, p59Hck, p61Hck, HCK proto-oncogene, Src family tyrosine kinase
Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.
Gene data
HCK- Name
- HCK proto-oncogene, Src family tyrosine kinase
- Type
- protein-coding
- Position
- 32,052,197–32,101,857 (+)
- Aliases
- AIPCV, JTK9, p59Hck, p61Hck
- Ensembl
- ENSG00000101336
- RefSeq RNA
- NM_001172129.3, NM_001172130.3, NM_001172131.3, NM_001172132.3, NM_001172133.3
- RefSeq protein
- NP_001165600.1, NP_001165601.1, NP_001165602.1, NP_001165603.1, NP_001165604.1
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
HCK proto-oncogene, Src family tyrosine kinase
- Symbol
- HCK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:32,052,197-32,101,857
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein HCK PDB 1ad5.png
Show 8 more facts
- HomoloGene ID
- 20489
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3055
- genomic start
- 32052197
- chromosome
- human chromosome 20
- genomic end
- 30689659
- cytogenetic location
- 20q11.21
- expressed in
- periodontal fiber
Sources (3)
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Signaling
- Function
- Interactions
- References
- Further reading
Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.
== Structure == HCK comprises five distinct domains which include two terminal domains and three SH domains. The N-terminal domain is important for lipid modifications and a C-terminal domain includes a regulatory tyrosine residue. Next, HCK comprises three highly conserved SH domains: SH1, SH2, and SH3. The catalytic SH1 domain houses the kinase's active site. The regulatory SH3 and SH2 domains are tightly bound together when HCK is in an inactive state.
Excerpted from Wikipedia’s “HCK” article, available under the CC BY-SA 4.0 licence.