bapineuzumab
Sign in to saveBapineuzumab (nicknamed "bapi") is a humanized monoclonal antibody that acts on the nervous system and may have potential therapeutic value for the treatment of Alzheimer's disease and possibly glaucoma. However, in 2012 it failed to produce significant cognitive improvements in patients in two major trials, despite lowering key biomarkers of AD, amyloid brain plaque and hyperphosphorylated tau protein in CSF.
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
Show 2 more facts
- chemical formula
- C₆₄₆₆H₁₀₀₁₈N₁₇₃₄O₂₀₂₆S₄₄
- subject has role
- monoclonal antibody
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Bapineuzumab (nicknamed "bapi") is a humanized monoclonal antibody that acts on the nervous system and may have potential therapeutic value for the treatment of Alzheimer's disease and possibly glaucoma. However, in 2012 it failed to produce significant cognitive improvements in patients in two major trials, despite lowering key biomarkers of AD, amyloid brain plaque and hyperphosphorylated tau protein in CSF.
Bapineuzumab has been shown to recognise the extreme N-terminal 5 residues of Aβ peptide in a helical conformation (4HIX.pdb) stabilized by internal hydrogen bonds involving the first three amino acids.
Excerpted from Wikipedia’s “bapineuzumab” article, available under the CC BY-SA 4.0 licence.