BCAR3

Name

BCAR3 adaptor protein, NSP family member

Type

protein-coding

Position

93,561,741–93,847,488 (−)

Aliases

AND-34, MIG7, NSP2, SH2D3B

Ensembl

ENSG00000137936

RefSeq RNA

NM_001261408.2, NM_001261409.1, NM_001261410.2, NM_001308251.1, NM_001412043.1

RefSeq protein

NP_001248337.1, NP_001248338.1, NP_001248339.1, NP_001295180.1, NP_001398972.1

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].

via MyGene.info

Gene · Ensembl

BCAR3 adaptor protein, NSP family member

Symbol

BCAR3

Biotype

Protein coding

Organism

Homo sapiens

Location

1:93,561,178-93,847,488

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0