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GeneQ18030365· pop 6· linked from 814 articles

PBX3

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Also known as PBX homeobox 3

Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene.

In the Vinony graph

Vinony's link graph records 814 inbound references to PBX3, and connects out to PubMed, human chromosome 9 and homeobox.

It is catalogued under topics including Genes on human chromosome 9 and Transcription factors.

Vinony links it to 6 Wikipedia language editions.

Gene data

PBX3

Name: PBX homeobox 3
Type: protein-coding
Position: 125,746,683–125,967,379 (+)
Ensembl: ENSG00000167081
RefSeq RNA: NM_001134778.2, NM_001330782.2, NM_001411009.1, NM_006195.6, NR_024122.2
RefSeq protein: NP_001128250.1, NP_001317711.1, NP_001397938.1, NP_006186.1, XP_011517057.1

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult locomotory behavior; dorsal spinal cord development; and regulation of respiratory gaseous exchange by nervous system process. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

eye development regulation of DNA-templated transcription anterior compartment pattern formation posterior compartment specification brain development animal organ morphogenesis positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus transcription regulator complex

Pathways

Transcriptional misregulation in cancer - Homo sapiens (human)Mesodermal commitment pathway miR-509-3p alteration of YAP1-ECM axis

via MyGene.info

Gene · Ensembl

PBX homeobox 3

Symbol: PBX3
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:125,746,683-125,967,379
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: HoxB1-Pbx1 heterodimer binding DNA 1b72.png

Show 8 more facts

HomoloGene ID: 21243
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5090
genomic end: 128729656
genomic start: 128509624
chromosome: human chromosome 9
cytogenetic location: 9q33.3
expressed in: vena cava

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
Further reading
External links

Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene.

==References==

Excerpted from Wikipedia’s “PBX3” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 9 Transcription factors