Structure via PubChem · Public domain (PubChem)
beta-leucine
Sign in to saveAlso known as 3-amino-4-methylpentanoic acid, 3-amino-4-methyl-pentanoic acid, 3-amino-4-methyl-valeric acid, β-leucine
β-Leucine ('''beta-leucine''') is a beta amino acid and positional isomer of -leucine which is naturally produced in humans via the metabolism of -leucine by the enzyme leucine 2,3-aminomutase. In cobalamin (vitamin B12) deficient individuals, plasma concentrations of β-leucine are elevated.
Chemical data
- Formula
- C6H13NO2
- Molecular weight
- 131.17 g/mol
- IUPAC name
- 3-amino-4-methylpentanoic acid
- SMILES
- CC(C)C(CC(=O)O)N
- InChIKey
- GLUJNGJDHCTUJY-UHFFFAOYSA-N
- XLogP
- -2.1
- Polar surface area
- 63.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 131.094629
Show 2 more facts
- chemical formula
- C₆H₁₃NO₂
- canonical SMILES
- CC(C)C(CC(=O)O)N
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Biosynthesis and metabolism in humans
- References
β-Leucine ('''beta-leucine''') is a beta amino acid and positional isomer of -leucine which is naturally produced in humans via the metabolism of -leucine by the enzyme leucine 2,3-aminomutase. In cobalamin (vitamin B12) deficient individuals, plasma concentrations of β-leucine are elevated.
==Biosynthesis and metabolism in humans== A small fraction of metabolism – less than 5% in all tissues except the testes where it accounts for about 33% – is initially catalyzed by leucine aminomutase, producing β-leucine, which is subsequently metabolized into (β-KIC), β-ketoisocaproyl-CoA, and then acetyl-CoA by a series of uncharacterized enzymes.
Excerpted from Wikipedia’s “beta-leucine” article, available under the CC BY-SA 4.0 licence.