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GeneQ18033101· pop 6· linked from 812 articles

BHLHE40

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Also known as BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14, basic helix-loop-helix family member e40, Clast5

Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.

Gene data

BHLHE40

Name: basic helix-loop-helix family member e40
Type: protein-coding
Position: 4,978,715–4,985,323 (+)
Aliases: BHLHB2, Clast5, DEC1, HLHB2, SHARP-2, SHARP2, STRA13, Stra14
Ensembl: ENSG00000134107
RefSeq RNA: NM_003670.3, XM_054348160.1, XM_054348161.1, XM_054348162.1
RefSeq protein: NP_003661.1, XP_054204135.1, XP_054204136.1, XP_054204137.1

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of DNA-templated transcription circadian rhythm circadian rhythm anterior/posterior pattern specification circadian regulation of gene expression

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleus cytoplasm cytoplasm

Pathways

Circadian rhythm - Homo sapiens (human)BMAL1:CLOCK,NPAS2 activates circadian expression Circadian clock Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Heart Development Mesodermal commitment pathway Glucocorticoid Receptor Pathway Nuclear Receptors Meta-Pathway Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

via MyGene.info

Gene · Ensembl

basic helix-loop-helix family member e40

Symbol: BHLHE40
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:4,978,715-4,985,323
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

4 sections

Contents

Function
References
Further reading
External links

Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.

== Function ==

Excerpted from Wikipedia’s “BHLHE40” article, available under the CC BY-SA 4.0 licence.

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