Fas cell surface death receptor

Protein · UniProt

Tumor necrosis factor receptor superfamily member 6

Gene

FAS

Organism

Homo sapiens (Human)

Length

335 aa

Molecular mass

37,732 Da

Evidence

1: Evidence at protein level

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)

• PHASE2COMPLETED
  Feasibility and Effects of Valaciclovir Treatment in Persons With Early Alzheimer's DiseaseHugo Lovheim · NCT02997982
• PHASE1COMPLETED
  Assess the Effectiveness of Atomoxetine in Children With Fetal Alcohol Syndrome and ADD/ADHDUniversity of Oklahoma · NCT00417794
• PHASE1/PHASE2UNKNOWN
  Prevention of Acute Graft Versus Host Disease in Patients Undergoing Allogeneic ApoGraft Stem Cell TransplantationCellect Biotechnology · NCT02828878
• COMPLETED
  Impact of Fas/FasL in Chemotherapy Response in Epithelial Ovarian CarcinomaRennes University Hospital · NCT02297958
• COMPLETED
  Effect of FAS and FAS Ligand Polymorphisms on Patients With Platinum-Based -Treated Malignant Pleural MesotheliomaAin Shams University · NCT02269878
• COMPLETED
  Serum Caspase 3, Annexin a2 and Soluble Fas Levels and EndometriosisBakirkoy Dr. Sadi Konuk Research and Training Hospital · NCT03020108

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

Image

Fas receptor.png

via Wikidata · CC0