Structure via PubChem · Public domain (PubChem)
brotizolam
Sign in to saveAlso known as Lendorm, WE-941, Brotizolamum, Bondormin
Brotizolam, sold under the brand name Lendormin, among others, is a sedative–hypnotic thienotriazolodiazepine drug, which is a benzodiazepine analog. It possesses anxiolytic, anticonvulsant, hypnotic, sedative, and skeletal muscle relaxant properties, and is considered to be similar in effect to other short-acting hypnotic benzodiazepines such as triazolam or midazolam. It is used in the short-term treatment of severe insomnia. Brotizolam is a highly potent and short-acting hypnotic, with a typical dose ranging from 0.125 to 0.25 milligrams, which is rapidly eliminated with an average hal
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 459984727
- Drug.IUPAC_name
- 2-Bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
- Drug.image
- Brotizolam.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 155
- Drug.image2
- Brotizolam ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Lendormin, others
- Drug.legal_BR
- B1
- Drug.legal_CA
- Schedule IV
- Drug.legal_US
- Unscheduled
- Drug.legal_UK
- Class C
- Drug.legal_DE
- Rx-only/Anlage III
- Drug.legal_UN
- Schedule IV
- Drug.routes_of_administration
- Oral
- Drug.bioavailability
- 48–95%
via Wikipedia infobox
Chemical data
- Formula
- C15H10BrClN4S
- Molecular weight
- 393.7 g/mol
- IUPAC name
- 4-bromo-7-(2-chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaene
- SMILES
- CC1=NN=C2N1C3=C(C=C(S3)Br)C(=NC2)C4=CC=CC=C4Cl
- InChIKey
- UMSGKTJDUHERQW-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 71.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1984
- Indications
- insomnia, anxiety, Dementia, depressive disorder
via ChEMBL · EBI
Research
240 papers- Brotizolam.2006
- Brotizolam. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy as an hypnotic.Drugs · 1988
- Effects of brotizolam as a co-agent with ketamine for induction of anaesthesia in calves.Veterinary journal (London, England : 1997) · 2023
- Remimazolam anaphylaxis in a patient not allergic to brotizolam: a case report and literature review.BMC anesthesiology · 2024
- Brotizolam, a triazolothienodiazepine, in insomnia.Clinical pharmacology and therapeutics · 1986
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 391.95
- Has use
- medication
Show 4 more facts
- chemical formula
- C₁₅H₁₀BrClN₄S
- canonical SMILES
- CC1=NN=C2N1C3=C(C=C(S3)Br)C(=NC2)C4=CC=CC=C4Cl
- defined daily dose
- 0.25
- Commons category
- Brotizolam
Sources (3)
via Wikidata · CC0
~7 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Side effects
- Contraindications
- Pharmacology
- Society and culture
- Abuse
- Brand names
- See also
- References
- Further reading
- External links
Brotizolam, sold under the brand name Lendormin, among others, is a sedative–hypnotic thienotriazolodiazepine drug, which is a benzodiazepine analog. It possesses anxiolytic, anticonvulsant, hypnotic, sedative, and skeletal muscle relaxant properties, and is considered to be similar in effect to other short-acting hypnotic benzodiazepines such as triazolam or midazolam. It is used in the short-term treatment of severe insomnia. Brotizolam is a highly potent and short-acting hypnotic, with a typical dose ranging from 0.125 to 0.25 milligrams, which is rapidly eliminated with an average half-life of 4.4 hours (range 3.6–7.9 hours).
It was patented in 1974 and came into medical use in 1984. Brotizolam is not approved for sale in the UK, United States or Canada. It is approved for sale in the Netherlands, Germany, Spain, Belgium, Luxembourg, Austria, Portugal, Israel, Italy, Taiwan, and Japan.
Excerpted from Wikipedia’s “brotizolam” article, available under the CC BY-SA 4.0 licence.