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amfecloral
Sign in to saveAlso known as Amphecloral
Amfecloral (INN) or amphecloral (USAN) is a combination drug containing a central nervous system (CNS) stimulant and anorectic drug, dextroamphetamine, as well as a CNS depressant and sedative-hypnotic, chloral hydrate.
In the Vinony graph
Vinony's link graph records 1,521 inbound references to amfecloral, and connects out to amphetamines, picrotoxin and phenethylamine.
Vinony files it under Anorectics, Drugboxes which contain changes to verified fields and Drugboxes which contain changes to watched fields.
Vinony links it to 4 Wikipedia language editions.
Chemical data
- Formula
- C11H12Cl3N
- Molecular weight
- 264.6 g/mol
- IUPAC name
- 2,2,2-trichloro-N-(1-phenylpropan-2-yl)ethanimine
- SMILES
- CC(CC1=CC=CC=C1)N=CC(Cl)(Cl)Cl
- InChIKey
- VBZDETYCYXPOAK-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 12.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 263.003532424
- Has use
- medication
Show 3 more facts
- chemical formula
- C₁₁H₁₂Cl₃N
- canonical SMILES
- CC(CC1=CC=CC=C1)\N=C\C(Cl)(Cl)Cl
- Commons category
- Amfecloral
Sources (2)
via Wikidata · CC0
~4 min read
Encyclopedic overview
8 sectionsContents
- Naming and Classification
- Synthesis and Pharmacology
- History
- Combination Drugs in the Twentieth Century
- Efficacy and Tolerability
- Discontinuation
- See also
- References
Amfecloral (INN) or amphecloral (USAN) is a combination drug containing a central nervous system (CNS) stimulant and anorectic drug, dextroamphetamine, as well as a CNS depressant and sedative-hypnotic, chloral hydrate.
Widely used for its anorectic properties, amfecloral was approved by the United States Food and Drug Administration as an anti-obesity drug and marketed and distributed under the brand name Acutran. Upon 1962 passage of the Kefauver-Harris Amendment, pressure grew to withdraw the product from the market, and in 1973, production ceased for Acutran and its generic formulation, concurrent with similar combination anorectics, Desbutal (methamphetamine-pentobarbital) and Obetrol (methamphetamine-dextroamphetamine).
Excerpted from Wikipedia’s “amfecloral” article, available under the CC BY-SA 4.0 licence.