File:Bruce_Beutler.jpg · Wikimedia Commons · See Wikimedia Commons
Bruce Beutler is an American scientist who studies how the immune system works and uses genetics to understand disease. His research matters because it has helped reveal fundamental mechanisms of how our bodies recognize and fight infections and other threats.
AI-generated from the Wikipedia summary — may contain errors.
Person · Open Library
- Works
- 5
Top works
- Immunology, phenotype first
- Toll-like receptor family members and their ligands
- Toll-like receptor family members and their ligands
- Immunology, Phenotype First
- Tumor Necrosis Factors
via Open Library + Wikidata
Music · MusicBrainz
- Type
- Person
- Gender
- Male
- Origin
- United States
- Active from
- 1949-09-23
Discography
via MusicBrainz · CC0
Recent publications · Crossref
5 total works indexed
- Full-length transcriptome assembly from RNA-Seq data without a reference genome
· 2011 · cited 19,169x
- Initial sequencing and analysis of the human genome
· 2001 · cited 18,520x
- Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data
· 2012 · cited 17,740x
- The value of the world's ecosystem services and natural capital
· 1997 · cited 16,058x
- Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
· 2002 · cited 15,922x
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Wikidata facts
- Official website
- www.utsouthwestern.edu/labs/beutler
- Image
- Nobel Prize 2011-Press Conference KI-DSC 7512.jpg
Show 4 more facts
- Commons category
- Bruce Beutler
- date of birth
- 1957-12-29
- name in native language
- Bruce Alan Beutler
- P8168
- Xiao Xin
Sources (15)
via Wikidata · CC0
~27 min read
Article
Bruce Alan Beutler (/ˈbɔɪtlər/ BOYT-lər; born December 29, 1957) is an American immunologist and geneticist. Together with Jules A. Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for "discoveries concerning the activation of innate immunity." Beutler discovered the long-elusive receptor for lipopolysaccharide (LPS; also known as endotoxin). He did so by identifying spontaneous mutations in the gene coding for mouse Toll-like receptor 4 (Tlr4) in two unrelated strains of LPS-refractory mice and proving they were responsible for that phenotype. Subsequently, and chiefly through the work of Shizuo Akira, other TLRs were shown to detect signature molecules of most infectious microbes, in each case triggering an innate immune response.
The other half of the Nobel Prize went to Ralph M. Steinman for "his discovery of the dendritic cell and its role in adaptive immunity."