Bruce Beutler
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Bruce Beutler is an American scientist who studies how the immune system works and uses genetics to understand disease. His research matters because it has helped reveal fundamental mechanisms of how our bodies recognize and fight infections and other threats.
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- Born
- 1957-12-29
- Works
- 5
Top works
- Immunology, phenotype first
- Toll-like receptor family members and their ligands
- Toll-like receptor family members and their ligands
- Immunology, Phenotype First
- Tumor Necrosis Factors
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Bruce Alan Beutler (/ˈbɔɪtlər/ BOYT-lər; born December 29, 1957) is an American immunologist and geneticist. Together with Jules A. Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for "discoveries concerning the activation of innate immunity." Beutler discovered the long-elusive receptor for lipopolysaccharide (LPS; also known as endotoxin). He did so by identifying spontaneous mutations in the gene coding for mouse Toll-like receptor 4 (Tlr4) in two unrelated strains of LPS-refractory mice and proving they were responsible for that phenotype. Subsequently, and chiefly through the work of Shizuo Akira, other TLRs were shown to detect signature molecules of most infectious microbes, in each case triggering an innate immune response.
The other half of the Nobel Prize went to Ralph M. Steinman for "his discovery of the dendritic cell and its role in adaptive immunity."
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1957 birthsAmerican AtheistsAmerican geneticistsAmerican immunologistsAmerican Nobel laureatesBLP articles lacking sources from August 2023BLP articles lacking sources from July 2020Howard Hughes Medical InvestigatorsJewish American medical doctorsJewish American scientistsJewish atheistsJewish biologists