BUB1B
Sign in to saveAlso known as BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B
Gen der Spezies Homo sapiens
Gene data
BUB1B- Name
- BUB1 mitotic checkpoint serine/threonine kinase B
- Type
- protein-coding
- Position
- 40,160,984–40,221,137 (+)
- Aliases
- BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1
- Ensembl
- ENSG00000156970
- RefSeq RNA
- NM_001211.6
- RefSeq protein
- NP_001202.5
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
mitotic spindle assembly checkpoint signalingmitotic spindle assembly checkpoint signalingmitotic spindle assembly checkpoint signalingmitotic spindle assembly checkpoint signalingmitotic spindle assembly checkpoint signalingregulation of sister chromatid segregationmeiotic sister chromatid cohesion, centromeric
Molecular function
Pathways
Cell cycle - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint componentsAmplification of signal from the kinetochoresInactivation of APC/C via direct inhibition of the APC/C complexAmplification of signal from unattached kinetochores via a MAD2 inhibitory signalSignal TransductionCell CycleAPC/C-mediated degradation of cell cycle proteinsCdc20:Phospho-APC/C mediated degradation of Cyclin A
via MyGene.info
Gene · Ensembl
BUB1 mitotic checkpoint serine/threonine kinase B
- Symbol
- BUB1B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:40,160,984-40,221,137
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 933
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/701
- chromosome
- human chromosome 15
- genomic start
- 40453224
- genomic end
- 40221123
- cytogenetic location
- 15q15.1
- expressed in
- trabecular bone
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