Structure via PubChem · Public domain (PubChem)
canrenone
Sign in to saveCanrenone, sold under the brand names Contaren, Luvion, Phanurane, and Spiroletan, is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone which is used as a diuretic in Europe, including in Italy and Belgium. It is also an important active metabolite of spironolactone, and partially accounts for its therapeutic effects.
Chemical data
- Formula
- C22H28O3
- Molecular weight
- 340.5 g/mol
- IUPAC name
- (8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
- SMILES
- C[C@]12CCC(=O)C=C1C=C[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]45CCC(=O)O5)C
- InChIKey
- UJVLDDZCTMKXJK-WNHSNXHDSA-N
- XLogP
- 2.7
- Polar surface area
- 43.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
426 papers- Canrenone Restores Vasorelaxation Impaired by Marinobufagenin in Human Preeclampsia.International journal of molecular sciences · 2022
- Clinical Efficacy of Canrenone in Restoring Sinus Rhythm in Patients With Atrial Fibrillation-A Pilot, Randomized, Double-Blind Study.Journal of cardiovascular pharmacology and therapeutics · 2025
- Antimineralocorticoids.Renal physiology and biochemistry · 1991
- Relative Efficacy of Spironolactone, Eplerenone, and cAnRenone in patients with Chronic Heart failure (RESEARCH): a systematic review and network meta-analysis of randomized controlled trials.Heart failure reviews · 2020
- Aldosterone receptor blockers spironolactone and canrenone: two multivalent drugs.Expert opinion on pharmacotherapy · 2014
via PubMed
Wikidata facts
- Mass
- 340.204
Show 5 more facts
- chemical formula
- C₂₂H₂₈O₃
- canonical SMILES
- CC12CCC(=O)C=C1C=CC3C2CCC4(C3CCC45CCC(=O)O5)C
- isomeric SMILES
- C[C@]12CCC(=O)C=C1C=C[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]45CCC(=O)O5)C
- subject has role
- antimineralocorticoid
- Commons category
- Canrenone
Sources (2)
via Wikidata · CC0
~4 min read
Encyclopedic overview
13 sectionsContents
- Medical uses
- Heart failure
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- As a metabolite
- History
- Society and culture
- Generic names
- Brand names
- Availability
- See also
- References
Canrenone, sold under the brand names Contaren, Luvion, Phanurane, and Spiroletan, is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone which is used as a diuretic in Europe, including in Italy and Belgium. It is also an important active metabolite of spironolactone, and partially accounts for its therapeutic effects.
==Medical uses== Canrenone has been found to be effective in the treatment of hirsutism in women.
Excerpted from Wikipedia’s “canrenone” article, available under the CC BY-SA 4.0 licence.
Available in 12 languages
via Wikidata sitelinks · CC0