File:Furosemide.svg · Wikimedia Commons · See Wikimedia Commons
furosemide
Sign in to saveAlso known as dihydroflumethiazide, methforylthiazidine, 4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid, 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid, 2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid, 4-chloro-5-sulfamoyl-N-furfuryl-anthranilic acid
Furosemide, sold under the brand name Lasix among others, is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. Furosemide may also be used for the treatment of high blood pressure. It can be taken intravenously or orally. When given intravenously, furosemide typically takes effect within five minutes; when taken orally, it typically metabolizes within an hour.
OverviewAI-generated
Furosemide is a chemical compound with the formula C₁₂H₁₁ClN₂O₅S. Its IUPAC name is 4-chloro-2-(furan-2-ylmethylazaniumyl)-5-sulfamoylbenzoate. The substance has a melting point of 206 and a mass of 330.008. It is assigned the MCN code 2935.90.21.
Chemical properties include a weight of 330.74, an xlogp of 2.7, and a topological polar surface area of 138. The molecule contains two hydrogen bond donors and six hydrogen bond acceptors, with a charge of 0. The defined daily dose for furosemide is 40.
The compound is referenced by 1,290 other encyclopedia articles. A search for furosemide in PubMed yields a count of 19,215 entries.
Synthesized by Vinony from 20 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.ChEBI
- 47426
- Drug.ChEMBL
- 35
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 461114978
- Drug.image
- Furosemide.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Furosemide-1Z9Y-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Lasix, Furoscix, others
- Drug.MedlinePlus
- a682858
- Drug.DailyMedID
- Furosemide
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- Oral (PO), intravenous (IV), intramuscular (IM), subcutaneous (SC)
- Drug.ATC_prefix
- C03
- Drug.ATC_suffix
- CA01
- Drug.legal_AU
- S4
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C12H11ClN2O5S
- Molecular weight
- 330.74 g/mol
- IUPAC name
- 4-chloro-2-(furan-2-ylmethylazaniumyl)-5-sulfamoylbenzoate
- SMILES
- C1=COC(=C1)C[NH2+]C2=CC(=C(C=C2C(=O)[O-])S(=O)(=O)N)Cl
- InChIKey
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 138 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
19,215 papers- Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part I).Clinical pharmacokinetics · 1990
- Furosemide (frusemide).IARC monographs on the evaluation of carcinogenic risks to humans · 1990
- Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part II).Clinical pharmacokinetics · 1990
- [Furosemide].Krankenpflege Journal · 1987
- [Furosemide and pancreatitis].Deutsche medizinische Wochenschrift (1946) · 1986
via PubMed
~14 min read
Encyclopedic overview
13 sectionsContents
- Medical uses
- Kidney disease
- Other information
- Adverse effects
- Interactions
- Mechanism of action
- Pharmacokinetics
- Names
- Veterinary uses
- Horses
- References
- Further reading
- External links
Furosemide, sold under the brand name Lasix among others, is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. Furosemide may also be used for the treatment of high blood pressure. It can be taken intravenously or orally. When given intravenously, furosemide typically takes effect within five minutes; when taken orally, it typically metabolizes within an hour.
Common side effects include orthostatic hypotension (decrease in blood pressure while standing, and associated lightheadedness), tinnitus (ringing in the ears), and photosensitivity (sensitivity to light). Potentially serious side effects include electrolyte abnormalities, low blood pressure, and hearing loss. It is recommended that serum electrolytes (especially potassium), serum carbon dioxide|, creatinine, BUN levels, and liver and kidney functioning be monitored in patients taking furosemide. It is also recommended to be alert for the occurrence of any potential blood dyscrasias.
Excerpted from Wikipedia’s “furosemide” article, available under the CC BY-SA 4.0 licence.