Gene data
CAPN2- Name
- calpain 2
- Type
- protein-coding
- Position
- 223,701,561–223,776,018 (+)
- Aliases
- CANP2, CANPL2, CANPml, mCANP
- Ensembl
- ENSG00000162909
- RefSeq RNA
- NM_001146068.2, NM_001748.5, XM_047431344.1, XM_054338935.1
- RefSeq protein
- NP_001139540.1, NP_001739.3, XP_047287300.1, XP_054194910.1
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Gene Ontology
Biological process
Molecular function
calcium-dependent cysteine-type endopeptidase activitycalcium-dependent cysteine-type endopeptidase activitycalcium-dependent cysteine-type endopeptidase activitycalcium-dependent cysteine-type endopeptidase activitycalcium-dependent cysteine-type endopeptidase activitycalcium-dependent cysteine-type endopeptidase activitycalcium ion bindingprotein binding
Pathways
Protein processing in endoplasmic reticulum - Homo sapiens (human)Apoptosis - Homo sapiens (human)Necroptosis - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Focal adhesion - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)Shigellosis - Homo sapiens (human)Degradation of the extracellular matrixExtracellular matrix organization
via MyGene.info
Gene · Ensembl
calpain 2
- Symbol
- CAPN2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:223,701,561-223,776,018
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CAPN2 PDB 1df0.png
Show 8 more facts
- HomoloGene ID
- 1326
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/824
- genomic end
- 223963720
- genomic start
- 223889295
- chromosome
- human chromosome 1
- cytogenetic location
- 1q41
- expressed in
- visceral pleura
Sources (4)
via Wikidata · CC0